Plague Inc.

25 Games with a sci-fi setting like Plague Inc. that you should try

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We filtered the 50 games similar to Plague Inc. down to the 25 that fit the “Sci-Fi” category. Sunless Sea, Pikmin and New World: Aeternum top the list, ranked by affinity and similarity score to Plague Inc..

iRank76/ 100

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GenreStrategySubgenreRTS

Tags

DarkSolo

Year 2012Dev Ndemic Creations

Quick answer

Within the “Sci-Fi” category, the closest game to Plague Inc. is Sunless Sea — scoring 92/100 on our similarity scale. Pikmin and New World: Aeternum follow close behind.

#1Sunless Sea92 #2Pikmin95 #3New World: Aeternum95 #4Dune II: The Building of a Dynasty95 #5Maia94

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The best games with a sci-fi setting like Plague Inc.

25 similar games foundUpdated July 2026

Handpicked by our similarity algorithm, these are the titles with the highest gameplay match to Plague Inc.. Each one has been evaluated across 8 real attributes — from combat style and progression mechanics to world structure and visual perspective — so every recommendation is based on how the game actually plays, not just its genre label.

92

Sunless Sea

GenreStrategySubgenreRTS

SoloDarkHorrorSci-FiIsometric

Steam👍 83%· 9.5KIGDB85· 4OC81· 28

Year 2015Dev Failbetter GamesOn Linux · PC · iOS

✓ Same family of real-time strategy games: real-time strategy, dark, oppressive atmosphere and horror setting

≠ Stands apart with survival mechanics, deep RPG systems and adventure storytelling, while skipping deep simulation

95

Pikmin

GenreStrategySubgenreRTS

SoloSci-FiIsometric

IGDB80· 1

Year 2001Dev Nintendo Entertainment Analysis & Development · Gradiente

✓ Same family of real-time strategy games: real-time strategy, setting scifi and single-player focus

≠ Where it differs: brings adventure storytelling, while skipping deep simulation

#3New World: Aeternum

95

New World: Aeternum

GenreStrategySubgenreRTS

SoloSci-Fi

Steam👍 48%· 529MC43OC72· 66

Year 2014Dev Elder Games · Headup GamesPlaytime ~4hOn PC

✓ Nearly identical: real-time strategy, setting scifi and single-player focus.

≠ Missing: deep simulation.

#4Dune II: The Building of a Dynasty

95

Dune II: The Building of a Dynasty

GenreStrategySubgenreRTS

SoloSci-FiIsometric

Year 1992Dev Westwood Studios · Virgin Games

✓ Nearly identical: real-time strategy, setting scifi and single-player focus.

≠ Missing: deep simulation.

94

Maia

GenreStrategySubgenreRTS

SoloSci-FiProceduralSandbox WorldSpace

Steam👍 44%· 1.1K

Year 2013Dev Simon Roth · Machine StudiosPlaytime ~1hOn PC · Apple Macintosh · Linux

✓ Both are real-time strategy games — sharing real-time strategy, deep simulation and setting scifi

≠ Where it differs: brings survival mechanics, sandbox freedom and procedural generation, while skipping dark, oppressive atmosphere

91

Frostpunk

GenreStrategySubgenreRTS

SoloDarkSci-FiIsometricNarrative

Steam👍 93%· 134KRAWG👍 88%· 1.1KMC85IGDB86· 9OC86· 103

Year 2018Dev 11 Bit Studios · 11 bit studiosPlaytime ~6hOn PC · PS · Xbox

✓ Fits the real-time strategy games cluster, with real-time strategy, deep simulation and dark, oppressive atmosphere

≠ Where it differs: brings survival mechanics, strong narrative focus and punishing difficulty, while skipping combat tactical

87

Homeworld

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

IGDB90· 1

Year 1999Dev Relic Entertainment · Sierra EntertainmentOn Linux · PC · Mac

✓ Both are real-time strategy games — sharing real-time strategy, combat tactical and setting scifi

≠ Where it differs: brings adventure storytelling and multiplayer gameplay, while skipping deep simulation

#8StarCraft II: Legacy of the Void

87

StarCraft II: Legacy of the Void

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

IGDB90· 8

Year 2015Dev Blizzard EntertainmentOn PC · Mac

✓ Fits the real-time strategy games cluster, with real-time strategy, combat tactical and setting scifi

≠ Where it differs: brings multiplayer gameplay, loot and gear systems and skill tree progression, while skipping deep simulation

#9StarCraft II: Heart of the Swarm

87

StarCraft II: Heart of the Swarm

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

IGDB89· 9

Year 2013Dev Blizzard EntertainmentOn PC · Mac

✓ Fits the real-time strategy games cluster, with real-time strategy, combat tactical and setting scifi

≠ Its own twist: multiplayer gameplay, while skipping deep simulation

#10Command & Conquer: Generals

87

Command & Conquer: Generals

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

Steam👍 88%· 2.0K

Year 2003Dev EA Pacific · Aspyr MediaOn PC · Mac

✓ Fits the real-time strategy games cluster, with real-time strategy, combat tactical and setting scifi

≠ Its own twist: multiplayer gameplay and base building, while skipping deep simulation

#11Command & Conquer

87

Command & Conquer

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

Steam👍 73%· 416

Year 1995Dev Westwood Studios · Virgin Interactive Entertainment (Europe) Ltd.On PC · Mac

✓ Same family of real-time strategy games: real-time strategy, combat tactical and setting scifi

≠ Its own twist: multiplayer gameplay and base building, while skipping deep simulation

#12Warhammer 40,000: Dawn of War - Dark Crusade

86

Warhammer 40,000: Dawn of War - Dark Crusade

GenreStrategySubgenreRTS

SoloTacticalDarkSci-FiIsometric

Steam👍 96%· 9.4KRAWG👍 88%· 319MC87IGDB84· 3

Year 2006Dev Relic Entertainment · SEGAPlaytime ~2hOn PC

✓ Both are real-time strategy games — sharing real-time strategy, dark, oppressive atmosphere and combat tactical

≠ Stands apart with melee combat, historical setting and multiplayer gameplay, while skipping deep simulation

#13Command & Conquer: Tiberian Sun

86

Command & Conquer: Tiberian Sun

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

Year 1999Dev Westwood Studios · Electronic ArtsOn PC

✓ Same family of real-time strategy games: real-time strategy, combat tactical and setting scifi

≠ Its own twist: post-apocalyptic world and multiplayer gameplay, while skipping deep simulation

#14Command & Conquer: Red Alert

86

Command & Conquer: Red Alert

GenreStrategySubgenreRTS

SoloTacticalSci-FiIsometricMultiplayer

Steam👍 79%· 382

Year 1996Dev Westwood Studios · Sony Computer EntertainmentOn PlayStation 3 · PC

✓ Fits the real-time strategy games cluster, with real-time strategy, combat tactical and setting scifi

≠ Its own twist: historical setting and multiplayer gameplay, while skipping deep simulation

86

Pikmin 3

GenreStrategySubgenreRTS

SoloSci-FiIsometricMultiplayer

IGDB86· 9

Year 2013Dev Nintendo EAD Software Development Group No.4 · Nintendo

✓ Fits the real-time strategy games cluster, with real-time strategy, setting scifi and single-player focus

≠ Stands apart with adventure storytelling and multiplayer gameplay, while skipping deep simulation

Complete list of games with a sci-fi setting like Plague Inc.

The full catalog of games sharing gameplay DNA with Plague Inc., ordered from highest to lowest similarity score. Use the filters above to narrow down by genre, setting or game mode and find the alternative that best fits your playstyle.

Dune 2000

Dune 2000

RTS

Imagine Earth

Imagine Earth

RTS · Simulation

The Mims Beginning

The Mims Beginning

RTS · Simulation

Command & Conquer: Red Alert 2

Command & Conquer: Red Alert 2

RTS

Star Wars: Empire at War

Star Wars: Empire at War

RTS · Turn-Based Strat

Impossible Creatures Steam Edition

Impossible Creatures Steam Edition

RTS · Simulation

Empire Earth

Empire Earth

RTS

StarCraft II: Wings of Liberty

StarCraft II: Wings of Liberty

RTS

Halo Wars

Halo Wars

RTS

Pikmin 2

Pikmin 2

RTS · Adventure

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