Destroy All Humans!

18 Games with a sci-fi setting like Destroy All Humans! that you should try

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We filtered the 50 games similar to Destroy All Humans! down to the 18 that fit the “Sci-Fi” category. Antichamber, Grow Home and Obduction top the list, ranked by affinity and similarity score to Destroy All Humans!.

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GenreAdventureSubgenreOpen World Action-Adventure

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Solo

Year 2005Dev Pandemic Studios

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Within the “Sci-Fi” category, the closest game to Destroy All Humans! is Antichamber — scoring 96/100 on our similarity scale. Grow Home and Obduction follow close behind.

#1Antichamber96 #2Grow Home96 #3Obduction95 #4Everybody's Gone to the Rapture94 #5The Witness94

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The best games with a sci-fi setting like Destroy All Humans!

18 similar games foundUpdated July 2026

Handpicked by our similarity algorithm, these are the titles with the highest gameplay match to Destroy All Humans!. Each one has been evaluated across 6 real attributes — from combat style and progression mechanics to world structure and visual perspective — so every recommendation is based on how the game actually plays, not just its genre label.

96

Antichamber

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationNarrative

Steam👍 95%· 18KRAWG👍 83%· 435MC82IGDB83· 6

Year 2013Dev Alexander Bruce · DemruthPlaytime ~3hOn PC · Apple Macintosh · Linux

✓ Same family of open-world adventures: adventure storytelling, open world exploration and setting scifi

≠ Its own twist: puzzle design, precision platforming and strong narrative focus, while skipping visual third person

96

Grow Home

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

Steam👍 92%· 5.6KIGDB78· 6OC76· 38

Year 2015Dev Ubisoft Reflections · Ubisoft EntertainmentOn PS4 · Linux · PC

✓ Fits the open-world adventures cluster, with adventure storytelling, open world exploration and setting scifi

≠ Where it differs: brings precision platforming, sandbox freedom and vibe casual

95

Obduction

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationNarrative

Steam👍 80%· 4.0KIGDB67· 9OC72· 37

Year 2016Dev Cyan WorldsOn PC · PS4 · iOS

✓ Fits the open-world adventures cluster, with adventure storytelling, open world exploration and setting scifi

≠ Its own twist: puzzle design, strong narrative focus and vibe casual, while skipping visual third person

#4Everybody's Gone to the Rapture

94

Everybody's Gone to the Rapture

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationNarrative

Steam👍 68%· 2.1KIGDB79· 11OC79· 72

Year 2015Dev The Chinese Room · Sony Computer EntertainmentOn PS4 · PC

✓ Fits the open-world adventures cluster, with adventure storytelling, open world exploration and setting scifi

≠ Stands apart with strong narrative focus, vibe casual and post-apocalyptic world, while skipping visual third person

94

The Witness

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationNarrative

Steam👍 85%· 21KRAWG👍 77%· 1.3KMC87IGDB88· 12OC86· 98

Year 2016Dev NVIDIA Lightspeed Studios · TheklaPlaytime ~4hOn PC · PS · Xbox

✓ Same family of open-world adventures: adventure storytelling, open world exploration and setting scifi

≠ Where it differs: brings puzzle design, strong narrative focus and punishing difficulty, while skipping visual third person

#6The Last Clockwinder

94

The Last Clockwinder

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationNarrative

Steam👍 96%· 784IGDB80· 1OC83· 12

Year 2022Dev pontoco · Cyan VenturesPlaytime ~6hOn PC · PS

✓ Both are open-world adventures — sharing adventure storytelling, open world exploration and setting scifi

≠ Its own twist: deep simulation, puzzle design and strong narrative focus, while skipping visual third person

93

Stray

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

Steam👍 97%· 171KRAWG👍 84%· 1.3KMC82IGDB85· 8OC84· 200

Year 2022Dev BlueTwelve · Annapurna InteractivePlaytime ~5hOn PC · PS · Xbox

✓ Fits the open-world adventures cluster, with adventure storytelling, open world exploration and setting scifi

≠ Stands apart with precision platforming, puzzle design and horror tension

#8Cosmic Osmo and the Worlds Beyond the Mackerel

93

Cosmic Osmo and the Worlds Beyond the Mackerel

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationCasual

Steam👍 79%· 115

Dev Cyan WorldsPlaytime ~1hOn PC

✓ Both are open-world adventures — sharing adventure storytelling, open world exploration and setting scifi

≠ Stands apart with puzzle design, horror tension and vibe casual, while skipping visual third person

#9Assassin's Creed: Bloodlines

93

Assassin's Creed: Bloodlines

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

IGDB45· 2

Year 2009Dev Ubisoft Montreal

✓ Fits the open-world adventures cluster, with adventure storytelling, open world exploration and setting scifi

≠ Its own twist: stealth mechanics, historical setting and setting medieval

93

Outer Wilds

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationMelee

Steam👍 96%· 102KIGDB85· 7OC85· 61

Year 2019Dev Mobius Digital · Annapurna InteractiveOn Xbox · PS4 · PC

✓ Both are open-world adventures — sharing adventure storytelling, open world exploration and setting scifi

≠ Stands apart with puzzle design, deep simulation and horror tension, while skipping visual third person

Steam Epic Xbox

93

Thief Gold

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationStealth

Steam👍 92%· 4.1KIGDB90· 1

Year 1999Dev Looking Glass Studios · Eidos InteractiveOn PC

✓ Both are open-world adventures — sharing adventure storytelling, open world exploration and setting scifi

≠ Where it differs: brings deep simulation, horror tension and dark, oppressive atmosphere, while skipping visual third person

#12The Legend of Zelda: Tears of the Kingdom

92

The Legend of Zelda: Tears of the Kingdom

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

IGDB95· 6OC95· 164

Year 2023Dev Nintendo EPD Production Group No. 3 · NintendoOn Switch

✓ Same family of open-world adventures: adventure storytelling, open world exploration and setting scifi

≠ Its own twist: puzzle design, sandbox freedom and sandbox world

#13The Legend of Zelda: Breath of the Wild

91

The Legend of Zelda: Breath of the Wild

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

IGDB98· 27OC96· 167

Year 2017Dev Nintendo EPD Production Group No. 3 · NintendoOn Switch

✓ Same family of open-world adventures: adventure storytelling, open world exploration and setting scifi

≠ Its own twist: puzzle design, sandbox freedom and sandbox world

#14X2: The Threat

91

X2: The Threat

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

Steam👍 83%· 522RAWG👍 58%· 36MC72IGDB67· 2

Year 2003Dev EgosoftPlaytime ~1hOn PC

✓ Same family of open-world adventures: open world exploration, setting scifi and single-player focus

≠ Stands apart with deep simulation, turn-based strategy and sandbox freedom, while skipping adventure storytelling

#15X: Beyond the Frontier

91

X: Beyond the Frontier

GenreAdventureSubgenreOpen World Action-Adventure

SoloOpen WorldSci-FiExplorationThird Person

Steam👍 75%· 387RAWG👍 56%· 32MC67IGDB30· 1

Year 1999Dev Egosoft · THQPlaytime ~1hOn PC

✓ Fits the open-world adventures cluster, with open world exploration, setting scifi and single-player focus

≠ Where it differs: brings deep simulation, sandbox freedom and turn-based strategy, while skipping adventure storytelling

Complete list of games with a sci-fi setting like Destroy All Humans!

The full catalog of games sharing gameplay DNA with Destroy All Humans!, ordered from highest to lowest similarity score. Use the filters above to narrow down by genre, setting or game mode and find the alternative that best fits your playstyle.

Assassin's Creed

Assassin's Creed

Adventure · Platformer

SpaceEngine

SpaceEngine

Simulation · Sandbox

Kerbal Space Program

Kerbal Space Program

Adventure · Simulation

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Rankings in the same genre

Best Open-World Adventure Games Best Adventure Games