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Destroy All Humans!

16 Games with a sci-fi setting like Destroy All Humans! that you should try

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We filtered the 50 games similar to Destroy All Humans! down to the 16 that fit the “Sci-Fi” category. Agents of Mayhem, High on Life and Control top the list, ranked by affinity and similarity score to Destroy All Humans!.

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GenreActionSubgenreOpen World Action
Tags
DarkSolo
Year 2020Dev Black Forest Games

Quick answer

Within the “Sci-Fi” category, the closest game to Destroy All Humans! is Agents of Mayhem — scoring 96/100 on our similarity scale. High on Life and Control follow close behind.

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The best games with a sci-fi setting like Destroy All Humans!

16 similar games foundUpdated July 2026

Handpicked by our similarity algorithm, these are the titles with the highest gameplay match to Destroy All Humans!. Each one has been evaluated across 12 real attributes — from combat style and progression mechanics to world structure and visual perspective — so every recommendation is based on how the game actually plays, not just its genre label.

Agents of Mayhem
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExplorationThird Person
Steam👍 58%· 4.9KIGDB73· 19OC67· 131
Year 2017Dev Volition · Deep SilverOn PS4 · PC · Xbox

✓ Same family of open-world action games: shooter, third-person shooting and adventure storytelling

≠ Its own twist: first-person shooting, while skipping sandbox freedom

High on Life
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExploration
Steam👍 89%· 25KIGDB69· 5OC69· 92
Year 2022Dev Squanch GamesOn Xbox · PS4 · PC

✓ Fits the open-world action games cluster, with shooter, adventure storytelling and dark, oppressive atmosphere

≠ Where it differs: brings first-person shooting, strong narrative focus and visual first person, while skipping third-person shooting

Control
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExplorationThird Person
Steam👍 86%· 60KIGDB83· 15OC84· 183
Year 2019Dev Remedy Entertainment · 505 GamesOn Xbox · PS4 · PC

✓ Same family of open-world action games: adventure storytelling, shooter and third-person shooting

≠ Where it differs: brings horror tension, first-person shooting and Metroidvania exploration, while skipping sandbox freedom

Vangers
ActionOpen World Action
SoloMeleeOpen WorldSandbox WorldSci-FiExploration
Steam👍 93%· 1.4KRAWG👍 77%· 83
Year 1998Dev K-D Lab · KranX ProductionsPlaytime ~1hOn PC · Apple Macintosh · Linux

✓ Same family of open-world action games: adventure storytelling, sandbox freedom and open world exploration

≠ Its own twist: racing gameplay, deep RPG systems and horror tension, while skipping shooter

Sonic Frontiers
ActionOpen World Action
SoloMeleeOpen WorldSci-FiExplorationThird Person
Steam👍 89%· 28KIGDB72· 8OC71· 137
Year 2022Dev Sonic Team · SegaOn Xbox · PS4 · PC

✓ Same family of open-world action games: adventure storytelling, open world exploration and melee combat

≠ Its own twist: precision platforming, deep RPG systems and action RPG combat, while skipping shooter

Ratchet & Clank: Rift Apart
ActionOpen World Action
SoloMeleeOpen WorldSci-FiExplorationThird Person
Steam👍 91%· 17KIGDB91· 15OC88· 200
Year 2021Dev Insomniac Games · Sony Interactive EntertainmentOn PC · PS5

✓ Same family of open-world action games: adventure storytelling, shooter and third-person shooting

≠ Stands apart with precision platforming, first-person shooting and strong narrative focus, while skipping sandbox freedom

Red Faction Guerrilla Steam Edition
ActionOpen World Action
SoloMeleeOpen WorldSandbox WorldSci-FiExplorationThird Person
Steam👍 90%· 7.7KRAWG👍 67%· 627MC82
Year 2009Dev THQ NordicPlaytime ~4hOn PC · PS · Xbox

✓ Same family of open-world action games: third-person shooting, shooter and sandbox freedom

≠ Where it differs: brings ranged combat and multiplayer gameplay, while skipping dark, oppressive atmosphere

Marvel’s Spider-Man Remastered
ActionOpen World Action
SoloMeleeOpen WorldSci-FiExplorationThird Person
Steam👍 96%· 132KRAWG👍 93%· 453OC87· 87
Year 2020Dev Insomniac Games · Sony Interactive EntertainmentPlaytime ~13hOn PC · PS

✓ Both are open-world action games — sharing adventure storytelling, open world exploration and melee combat

≠ Stands apart with vibe casual, strong narrative focus and stealth mechanics, while skipping shooter

Gears 5
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExplorationThird Person
Steam👍 71%· 24KIGDB88· 12OC85· 150
Year 2019Dev The Coalition · Xbox Game StudiosOn Xbox · PC

✓ Both are open-world action games — sharing adventure storytelling, shooter and third-person shooting

≠ Its own twist: first-person shooting, strong narrative focus and multiplayer gameplay, while skipping sandbox freedom

Red Faction: Armageddon
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExplorationThird Person
Steam👍 73%· 5.0KIGDB75· 5
Year 2011Dev Volition · THQOn PlayStation 3 · PC

✓ Same family of open-world action games: shooter, third-person shooting and adventure storytelling

≠ Its own twist: first-person shooting, linear, story-driven structure and horror setting, while skipping sandbox freedom

Crysis Warhead
ActionOpen World Action
SoloMeleeOpen WorldSci-FiExplorationThird Person
Steam👍 86%· 4.1KIGDB77· 3
Year 2008Dev Crytek Budapest · Electronic ArtsOn PC

✓ Same family of open-world action games: shooter, adventure storytelling and open world exploration

≠ Where it differs: brings first-person shooting, stealth mechanics and combat tactical, while skipping third-person shooting

Wolfenstein II: The New Colossus
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExploration
Steam👍 81%· 48KIGDB87· 22
Year 2017Dev MachineGames · Bethesda SoftworksOn PS4 · PC · Xbox

✓ Fits the open-world action games cluster, with shooter, adventure storytelling and dark, oppressive atmosphere

≠ Its own twist: first-person shooting, strong narrative focus and combat tactical, while skipping third-person shooting

Metal Gear Solid V: Ground Zeroes
ActionOpen World Action
SoloMeleeOpen WorldSandbox WorldSci-FiExplorationThird Person
Steam👍 85%· 18KIGDB79· 19OC75· 81
Year 2014Dev Kojima Productions · KonamiOn PlayStation 3 · PS4 · PC

✓ Fits the open-world action games cluster, with adventure storytelling, shooter and third-person shooting

≠ Its own twist: first-person shooting, strong narrative focus and stealth mechanics, while skipping dark, oppressive atmosphere

Serious Sam 4
ActionOpen World Action
SoloMeleeDarkOpen WorldSci-FiExploration
Steam👍 83%· 17KIGDB72· 9OC68· 105
Year 2020Dev Croteam · Devolver DigitalOn Xbox · Linux · PC

✓ Both are open-world action games — sharing shooter, adventure storytelling and dark, oppressive atmosphere

≠ Where it differs: brings first-person shooting, punishing difficulty and multiplayer gameplay, while skipping third-person shooting

Twinsen's Little Big Adventure 2 Classic
ActionOpen World Action
SoloMeleeOpen WorldSci-FiExplorationThird Person
Steam👍 97%· 914RAWG👍 74%· 77
Year 1997Dev DotEmu · Electronic ArtsPlaytime ~1hOn PC · Apple Macintosh

✓ Fits the open-world action games cluster, with adventure storytelling, open world exploration and melee combat

≠ Stands apart with puzzle design, precision platforming and strong narrative focus, while skipping shooter

Complete list of games with a sci-fi setting like Destroy All Humans!

The full catalog of games sharing gameplay DNA with Destroy All Humans!, ordered from highest to lowest similarity score. Use the filters above to narrow down by genre, setting or game mode and find the alternative that best fits your playstyle.

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